<section style="font-size: 16px;" data-role="outer"> <p>&nbsp;</p> <section style="outline-width: 0px; color: #344c50; font-size: 16px; visibility: visible;"> <section style="outline-width: 0px; text-align: center; line-height: 0; visibility: visible;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; visibility: visible;"></section> </section> <section style="outline-width: 0px; visibility: visible;"> <section style="outline-width: 0px; text-align: center; line-height: 0; visibility: visible;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; visibility: visible;"></section> </section> <section style="outline-width: 0px; visibility: visible;"> <section style="outline-width: 0px; text-align: center; line-height: 0; visibility: visible;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; visibility: visible;"></section> </section> <section style="outline-width: 0px; visibility: visible;"> <section style="outline-width: 0px; text-align: center; line-height: 0; visibility: visible;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; visibility: visible;"></section> </section> <section style="outline-width: 0px; visibility: visible;"> <section style="outline-width: 0px; text-align: center; line-height: 0; visibility: visible;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; visibility: visible;"></section> </section> <section style="outline-width: 0px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; visibility: visible;"> <section style="outline-width: 0px; display: inline-block; width: 596px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(233, 252, 248, 0.1); visibility: visible;"> <section style="outline-width: 0px; transform-style: flat; visibility: visible; transform: perspective(0px) rotateZ(180deg);"> <section style="outline-width: 0px; opacity: 0.86; visibility: visible; transform: rotateX(180deg) rotateY(180deg);"> <section style="outline-width: 0px; display: inline-block; width: 130px; height: 80px; vertical-align: top; overflow: hidden; background-image: linear-gradient(to right bottom, #288c83, #61a8a0, #91c5bf, #bfe2de, #eefffd); visibility: visible;"></section> </section> </section> <section style="margin-top: -35px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; visibility: visible;"> <section style="outline-width: 0px; display: inline-block; width: 447px; vertical-align: top; flex: 0 0 auto; height: auto; background-color: rgba(236, 236, 236, 0.8); align-self: flex-start; visibility: visible;"> <section style="outline-width: 0px; text-align: justify; visibility: visible;"> <p style="outline-width: 0px; visibility: visible;">&nbsp;</p> </section> <section style="outline-width: 0px; justify-content: center; display: flex; flex-flow: row nowrap; visibility: visible;"> <section style="outline-width: 0px; display: inline-block; width: 447px; vertical-align: top; background-position: 50% 50%; background-repeat: no-repeat; background-size: cover; background-attachment: scroll; align-self: flex-start; flex: 0 0 auto; background-image: url('https://editor-user.365editor.com/wechat/99/82/4969882/1684741828179411.jpeg'); visibility: visible;"> <section style="outline-width: 0px; justify-content: center; display: flex; flex-flow: row nowrap; opacity: 1; visibility: visible;"> <section style="outline-width: 0px; display: inline-block; width: 447px; vertical-align: top; background-color: rgba(255, 255, 255, 0.37); align-self: flex-start; flex: 0 0 auto; visibility: visible;"> <section style="outline-width: 0px; text-align: justify; visibility: visible;"> <p style="outline-width: 0px; visibility: visible;">&nbsp;</p> </section> <section style="margin-top: 10px; margin-bottom: 10px; outline-width: 0px; visibility: visible;"> <section style="outline-width: 0px; font-size: 32px; color: #004c47; line-height: 1.3; text-shadow: #fafcf7 1px -1px, #fafcf7 1px 1px, #fafcf7 -1px 1px, #fafcf7 -1px -1px, #fafcf7 1px 0px, #fafcf7 0px 1px, #fafcf7 -1px 0px, #fafcf7 0px -1px; visibility: visible;"> <p style="outline-width: 0px; visibility: visible;"><strong style="outline-width: 0px; visibility: visible;">科研成果</strong></p> </section> </section> <section style="outline-width: 0px; display: flex; flex-flow: row nowrap; justify-content: center; visibility: visible;"> <section style="outline-width: 0px; display: inline-block; vertical-align: middle; width: auto; flex: 100 100 0%; align-self: center; height: auto; visibility: visible;"> <section style="margin-top: 6px; margin-bottom: 8px; outline-width: 0px;"> <section style="outline-width: 0px; background-color: #288c83; height: 1px;"></section> </section> </section> <section style="margin-right: 20px; margin-left: 20px; outline-width: 0px; display: inline-block; vertical-align: middle; width: auto; min-width: 10%; flex: 0 0 auto; height: auto; align-self: center;"> <section style="outline-width: 0px; font-size: 14px; line-height: 1.8; color: #004c47; text-align: justify;"> <p style="outline-width: 0px;">港大醫(yī)學(xué)院研究團隊</p> </section> </section> <section style="outline-width: 0px; display: inline-block; vertical-align: middle; width: auto; flex: 100 100 0%; align-self: center; height: auto;"> <section style="margin-top: 6px; margin-bottom: 8px; outline-width: 0px;"> <section style="outline-width: 0px; background-color: #288c83; height: 1px;"></section> </section> </section> </section> <section style="outline-width: 0px; font-size: 14px; color: #004c47; text-align: justify;"> <p style="outline-width: 0px; text-align: center;">2023.05</p> </section> <section style="outline-width: 0px; text-align: justify;"> <p style="outline-width: 0px;">&nbsp;</p> </section> <section style="outline-width: 0px; text-align: justify;"> <p style="outline-width: 0px;">&nbsp;</p> </section> </section> </section> </section> </section> </section> </section> <section style="outline-width: 0px; text-align: justify; justify-content: flex-start; display: flex; flex-flow: row nowrap;"> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: 298px; align-self: flex-start; flex: 0 0 auto;"> <section style="margin-top: -35px; outline-width: 0px; text-align: left; transform: translate3d(20px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 60px; height: 35px; vertical-align: top; overflow: hidden; background-color: rgba(236, 236, 236, 0.84);"></section> </section> </section> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: 298px; align-self: flex-start; flex: 0 0 auto;"> <section style="margin-top: -50px; outline-width: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row nowrap;"> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: auto; min-width: 10%; flex: 0 0 auto; height: auto; align-self: flex-start;"> <section style="outline-width: 0px; text-align: left;"> <section style="outline-width: 0px; display: inline-block; width: 20px; height: 50px; vertical-align: top; overflow: hidden; background-color: rgba(69, 194, 184, 0.2);"></section> </section> </section> <section style="padding-left: 10px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; min-width: 10%; flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="outline-width: 0px; text-align: left;"> <section style="outline-width: 0px; display: inline-block; width: 40px; height: 50px; vertical-align: top; overflow: hidden; background-image: linear-gradient(to top, #b1e0e0, #c2e7e8, #d3eff0, #e3f6f8, #f4feff);"></section> </section> </section> </section> </section> </section> </section> </section> <section style="margin-top: 30px; margin-bottom: 20px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="outline-width: 0px; display: inline-block; width: 548.312px; vertical-align: top; flex: 0 0 auto; height: auto; border-right: 0px solid #3e3e3e; border-top-right-radius: 0px; align-self: flex-start; box-sizing: border-box;"> <section style="margin-top: 15px; margin-bottom: 10px; outline-width: 0px;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; line-height: 1.8; color: #3e3e3e; text-align: justify; box-sizing: border-box;"> <p style="outline-width: 0px;">香港大學(xué)新發(fā)傳染性疾病國家重點實驗室及香港大學(xué)李嘉誠醫(yī)學(xué)院(港大醫(yī)學(xué)院)臨床醫(yī)學(xué)學(xué)院微生物學(xué)系周婕博士與袁國勇教授團隊，聯(lián)同類器官先驅(qū)、荷蘭Hubrecht Institute的Hans Clevers教授及復(fù)旦大學(xué)姜世勃教授<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">利用人呼吸道類器官模型，評估Omicron BA.5及其他變異株在人體呼吸道細胞中感染和復(fù)制能力。</strong></span></p> <p style="outline-width: 0px;">&nbsp;</p> <p style="outline-width: 0px;">研究結(jié)果已發(fā)表于最新一期的《美國國家科學(xué)院院刊》(PNAS)。</p> </section> </section> </section> </section> <section style="margin-bottom: -35px; outline-width: 0px; text-align: left; transform: translate3d(15px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 50px; height: 50px; vertical-align: top; overflow: hidden; border-radius: 100%; background-image: linear-gradient(to top, #76b0a6 0%, #86cabf 100%); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 5px; outline-width: 0px; text-align: center;"> <section style="outline-width: 0px; display: inline-block; width: 40px; height: 40px; vertical-align: top; overflow: hidden; border-radius: 100%; background-color: rgba(255, 255, 255, 0.98); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 4px; outline-width: 0px;"> <section style="outline-width: 0px; font-size: 20px; color: #004c47;"> <p style="outline-width: 0px;"><em style="outline-width: 0px;"><strong style="outline-width: 0px;">01</strong></em></p> </section> </section> </section> </section> <section style="outline-width: 0px; text-align: justify;"> <p style="outline-width: 0px;">&nbsp;</p> </section> </section> </section> <section style="margin-bottom: 15px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding-left: 70px; outline-width: 0px; display: inline-block; width: 596px; vertical-align: top; border-left: 8px double rgba(255, 255, 255, 0.98); border-bottom-left-radius: 0px; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right, #288c83, #59a8a0, #83c4bd, #ace1db, #d5fffa); box-sizing: border-box;"> <section style="margin-top: 6px; margin-bottom: 6px; outline-width: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row nowrap;"> <section style="padding-right: 15px; padding-left: 20px; outline-width: 0px; display: inline-block; width: 518px; vertical-align: top; border-left: 0px none #3e3e3e; border-bottom-left-radius: 30px; overflow: hidden; border-bottom: 0px none #3e3e3e; border-bottom-right-radius: 0px; border-top: 0px none #3e3e3e; border-top-left-radius: 30px; background-color: rgba(255, 255, 255, 0.98); flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="outline-width: 0px; transform: translate3d(1px, 0px, 0px);"> <section style="outline-width: 0px; text-align: left; font-size: 18px; color: #004c47;"> <p style="outline-width: 0px;"><strong style="outline-width: 0px;">研究背景</strong></p> </section> </section> </section> </section> </section> </section> <section style="margin-top: 15px; margin-bottom: 10px; outline-width: 0px;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">新冠病毒變異株在世界各地引發(fā)了多次感染高峰。其中，Omicron變異株于2021年11月在南非首次發(fā)現(xiàn)，并迅速在全球傳播。</p> </section> </section> <section style="margin-top: 20px; margin-bottom: 20px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding: 15px; outline-width: 0px; display: inline-block; width: 536.396px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; border-radius: 5px; overflow: hidden; background-color: #f7f6f9; height: auto; box-sizing: border-box; border: 2px solid #08706a;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; text-align: justify; font-size: 14px; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;"><span style="outline-width: 0px; color: #3e3e3e;">高傳染性的Omicron相比之前的變異株更容易逃避抗體的中和，導(dǎo)致免疫逃逸，從而增加在免疫人群中感染或再次感染的機會。</span></p> </section> </section> </section> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">然而，科學(xué)家也在思考另幾個重要議題：新冠病毒在演變過程中，是否強化了其在人類呼吸道細胞內(nèi)生長復(fù)制的能力，導(dǎo)致傳播能力增強？Omicron變異株是否已在人類呼吸道細胞內(nèi)適應(yīng)了？</p> <p style="outline-width: 0px;">&nbsp;</p> <p style="outline-width: 0px;">要回答這些問題，<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">需要一個可以模擬人類呼吸道上皮的體外模型，以測試病毒在人類呼吸細胞中的感染和復(fù)制。</strong></span></p> </section> <p style="outline-width: 0px;">&nbsp;</p> <section style="margin-bottom: -35px; outline-width: 0px; text-align: left; transform: translate3d(15px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 50px; height: 50px; vertical-align: top; overflow: hidden; border-radius: 100%; background-image: linear-gradient(to top, #76b0a6 0%, #86cabf 100%); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 5px; outline-width: 0px; text-align: center;"> <section style="outline-width: 0px; display: inline-block; width: 40px; height: 40px; vertical-align: top; overflow: hidden; border-radius: 100%; background-color: rgba(255, 255, 255, 0.98); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 4px; outline-width: 0px;"> <section style="outline-width: 0px; font-size: 20px; color: #004c47;"> <p style="outline-width: 0px;"><em style="outline-width: 0px;"><strong style="outline-width: 0px;">02</strong></em></p> </section> </section> </section> </section> <section style="outline-width: 0px; text-align: justify;"> <p style="outline-width: 0px;">&nbsp;</p> </section> </section> </section> <section style="margin-bottom: 15px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding-left: 70px; outline-width: 0px; display: inline-block; width: 596px; vertical-align: top; border-left: 8px double rgba(255, 255, 255, 0.98); border-bottom-left-radius: 0px; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right, #288c83, #59a8a0, #83c4bd, #ace1db, #d5fffa); box-sizing: border-box;"> <section style="margin-top: 6px; margin-bottom: 6px; outline-width: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row nowrap;"> <section style="padding-right: 15px; padding-left: 20px; outline-width: 0px; display: inline-block; width: 518px; vertical-align: top; border-left: 0px none #3e3e3e; border-bottom-left-radius: 30px; overflow: hidden; border-bottom: 0px none #3e3e3e; border-bottom-right-radius: 0px; border-top: 0px none #3e3e3e; border-top-left-radius: 30px; background-color: rgba(255, 255, 255, 0.98); flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="outline-width: 0px; transform: translate3d(1px, 0px, 0px);"> <section style="outline-width: 0px; text-align: left; font-size: 18px; color: #004c47;"> <p style="outline-width: 0px;"><strong style="outline-width: 0px;">研究方法和結(jié)果</strong></p> </section> </section> </section> </section> </section> </section> <section style="margin-top: 20px; outline-width: 0px;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; line-height: 1.8; color: #3e3e3e; box-sizing: border-box;"> <p style="outline-width: 0px;">周婕博士及袁國勇教授團隊與Hans Clevers教授合作，<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">建立了全球首個源自肺成體干細胞及鼻腔細胞的呼吸道類器官培養(yǎng)系統(tǒng)。</strong></span>這些呼吸道類器官可以連續(xù)穩(wěn)定地擴增半年至一年的時間。團隊將長期擴增培養(yǎng)的類器官誘導(dǎo)分化，建立了成熟的鼻粘膜、氣道和肺泡類器官(PNAS 2018，Cell Discovery 2022，mBio 2022)。</p> </section> </section> <section style="margin-top: 20px; margin-bottom: 20px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding-right: 5px; padding-left: 5px; outline-width: 0px; display: inline-block; width: 566.198px; vertical-align: top; box-shadow: #3e3e3e 0px 0px 0px; align-self: flex-start; flex: 0 0 auto; height: auto; box-sizing: border-box;"> <section style="margin-bottom: -1px; outline-width: 0px; text-align: right; justify-content: flex-end; font-size: 0px; display: flex; flex-flow: row nowrap; transform: translate3d(-1px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 278.094px; vertical-align: top; flex: 0 0 auto; height: auto; line-height: 0; align-self: flex-start;"> <section style="outline-width: 0px; display: flex; flex-flow: row nowrap; justify-content: flex-end;"> <section style="padding-right: 5px; padding-left: 5px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; background-color: #ffffff; flex: 1 1 0%; align-self: flex-start; height: auto; box-sizing: border-box;"> <section style="margin-top: 0.5em; margin-bottom: 0.5em; outline-width: 0px;"> <section style="outline-width: 0px; background-color: #08706a; height: 1px;"></section> </section> </section> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: auto; background-color: #ffffff; flex: 1 1 0%; height: auto; align-self: flex-start;"> <section style="margin-top: 0.5em; margin-bottom: 0.5em; outline-width: 0px;"> <section style="outline-width: 0px; background-color: #08706a; height: 1px;"></section> </section> </section> </section> </section> </section> <section style="outline-width: 0px; text-align: justify; justify-content: flex-start; display: flex; flex-flow: row nowrap;"> <section style="outline-width: 0px; display: inline-block; width: 556.198px; vertical-align: top; box-shadow: rgba(240, 207, 222, 0.11) 5px 5px 0px; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box; border: 1px solid #08706a;"> <section style="outline-width: 0px; justify-content: flex-start; display: flex; flex-flow: row nowrap;"> <section style="padding: 15px 10px 10px 15px; outline-width: 0px; display: inline-block; width: 554.198px; vertical-align: top; background-color: rgba(240, 207, 222, 0.11); box-shadow: #ffffff 5px 5px 0px inset; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; color: #3e3e3e; font-size: 14px; line-height: 2; box-sizing: border-box;"> <p style="outline-width: 0px;">這全新的呼吸道類器官培養(yǎng)系統(tǒng)使科學(xué)家能夠在培養(yǎng)皿中高效而穩(wěn)定地建立及擴增整個人類呼吸上皮組織，<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">這些呼吸道類器官成為研究呼吸道生物學(xué)，以及包括COVID-19在內(nèi)相關(guān)疾病的最佳工具。</strong></span></p> </section> </section> </section> </section> </section> <section style="margin-top: -1px; outline-width: 0px; text-align: left; justify-content: flex-start; font-size: 0px; display: flex; flex-flow: row nowrap;"> <section style="outline-width: 0px; display: inline-block; width: 278.094px; vertical-align: top; flex: 0 0 auto; height: auto; line-height: 0; align-self: flex-start;"> <section style="outline-width: 0px; display: flex; flex-flow: row nowrap; justify-content: flex-start;"> <section style="padding-right: 5px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; background-color: #ffffff; flex: 2 2 0%; align-self: flex-start; height: auto; box-sizing: border-box;"> <section style="margin-top: 0.5em; margin-bottom: 0.5em; outline-width: 0px;"> <section style="outline-width: 0px; background-color: #08706a; height: 1px;"></section> </section> </section> <section style="padding-right: 5px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; background-color: #ffffff; flex: 1 1 0%; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="margin-top: 0.5em; margin-bottom: 0.5em; outline-width: 0px;"> <section style="outline-width: 0px; background-color: #08706a; height: 1px;"></section> </section> </section> </section> </section> </section> </section> </section> <section style="margin-top: 20px; margin-bottom: 5px; outline-width: 0px; text-align: center; line-height: 0;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 566.198px; height: auto;"><img class="rich_pages wxw-img" style="outline-width: 0px; vertical-align: middle; width: 100%; height: auto; max-width: 100%; visibility: visible;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830882858.gif" width="566" height="481" data-backh="481" data-backw="566" data-ratio="0.8490740740740741" data-type="jpeg" data-w="1080" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830882858.gif" /></section> </section> <section style="outline-width: 0px; text-align: center;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; text-align: justify; font-size: 12px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">團隊將長期擴增培養(yǎng)的呼吸道類器官誘導(dǎo)分化，建立了成熟的鼻粘膜、氣道和肺泡類器官。</p> </section> </section> <p style="outline-width: 0px;">&nbsp;</p> <section style="margin-top: 30px; margin-bottom: 20px; outline-width: 0px; display: flex; flex-flow: row nowrap; justify-content: flex-start; transform: translate3d(10px, 0px, 0px);"> <section style="margin-right: 10px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; min-width: 10%; flex: 0 0 auto; height: auto;"> <section style="outline-width: 0px; text-align: left;"> <section style="outline-width: 0px; display: inline-block; width: 26px; height: 26px; vertical-align: top; overflow: hidden; box-sizing: border-box; border: 1px dashed #08706a;"> <section style="outline-width: 0px; transform: rotateZ(315deg);"> <section style="margin-top: 5px; outline-width: 0px; text-align: center; transform: translate3d(9px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 23px; height: 14px; vertical-align: top; overflow: hidden; border-style: solid; border-width: 0px 0px 3px 3px; border-color: #dd522c #dd522c #08706a #08706a; box-sizing: border-box;"></section> </section> </section> </section> </section> </section> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 100 100 0%; height: auto;"> <section style="outline-width: 0px; text-align: left; transform: translate3d(-10px, 0px, 0px);"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; text-align: justify; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">研究團隊首先在氣道類器官及鼻粘膜類器官中研究原始病毒株(WT)、兩種Omicron變異株B.1.1.529和BA.5的感染和復(fù)制情況。結(jié)果顯示，<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">BA.5感染類器官后產(chǎn)生的病毒滴度比WT和B.1.1.529更高，更達到與造成流感大流行的甲型流感病毒H1N1(H1N1pdm)相當(dāng)?shù)膹?fù)制能力。</strong></span></p> </section> </section> </section> </section> <section style="margin-top: 20px; margin-bottom: 20px; outline-width: 0px; display: flex; flex-flow: row nowrap; justify-content: flex-start; transform: translate3d(10px, 0px, 0px);"> <section style="margin-right: 10px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; min-width: 10%; flex: 0 0 auto; height: auto;"> <section style="outline-width: 0px; text-align: left;"> <section style="outline-width: 0px; display: inline-block; width: 26px; height: 26px; vertical-align: top; overflow: hidden; box-sizing: border-box; border: 1px dashed #08706a;"> <section style="outline-width: 0px; transform: rotateZ(315deg);"> <section style="margin-top: 5px; outline-width: 0px; text-align: center; transform: translate3d(9px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 23px; height: 14px; vertical-align: top; overflow: hidden; border-style: solid; border-width: 0px 0px 3px 3px; border-color: #dd522c #dd522c #08706a #08706a; box-sizing: border-box;"></section> </section> </section> </section> </section> </section> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 100 100 0%; height: auto;"> <section style="outline-width: 0px; text-align: left; transform: translate3d(-10px, 0px, 0px);"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; text-align: justify; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">團隊將病毒感染后的類器官進行了免疫染色和共聚焦成像。結(jié)果指出BA.5感染的鼻粘膜和氣道類器官中，病毒陽性細胞的數(shù)量明顯比B.1.1.529和WT增多。</p> </section> </section> </section> </section> <section style="margin-top: 20px; margin-bottom: 25px; outline-width: 0px; display: flex; flex-flow: row nowrap; justify-content: flex-start; transform: translate3d(10px, 0px, 0px);"> <section style="margin-right: 10px; outline-width: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; min-width: 10%; flex: 0 0 auto; height: auto;"> <section style="outline-width: 0px; text-align: left;"> <section style="outline-width: 0px; display: inline-block; width: 26px; height: 26px; vertical-align: top; overflow: hidden; box-sizing: border-box; border: 1px dashed #08706a;"> <section style="outline-width: 0px; transform: rotateZ(315deg);"> <section style="margin-top: 5px; outline-width: 0px; text-align: center; transform: translate3d(9px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 23px; height: 14px; vertical-align: top; overflow: hidden; border-style: solid; border-width: 0px 0px 3px 3px; border-color: #dd522c #dd522c #08706a #08706a; box-sizing: border-box;"></section> </section> </section> </section> </section> </section> <section style="outline-width: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 100 100 0%; height: auto;"> <section style="outline-width: 0px; text-align: left; transform: translate3d(-10px, 0px, 0px);"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; text-align: justify; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">除此之外，團隊亦發(fā)現(xiàn)BA.5感染后的氣道類器官和鼻粘膜類器官可以形成典型的多核合胞體，而WT和B.1.1.529的感染并不能產(chǎn)生合胞體。</p> </section> </section> </section> </section> <section style="outline-width: 0px;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;"><span style="outline-width: 0px; color: #3e3e3e;">總體來說，<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">BA.5的高感染效率和融合活性使人鼻粘膜和氣道細胞形成合胞體并促進病毒的擴散，從而顯著增強了感染力和傳播力。</strong></span></span></p> </section> </section> <section style="margin-top: 20px; margin-bottom: 5px; outline-width: 0px; text-align: center; line-height: 0;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0;"><img class="rich_pages wxw-img" style="outline-width: 0px; vertical-align: middle; width: 571px; height: 238px; max-width: 100%; visibility: visible;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830417983.gif" width="571" height="238" data-backh="241" data-backw="578" data-ratio="0.41759259259259257" data-type="png" data-w="1080" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830417983.gif" /></section> </section> <section style="outline-width: 0px; text-align: center;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; text-align: justify; font-size: 12px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">鼻粘膜類器官分別以0.01MOI的病毒量感染SARS-CoV-2 WT和BA.5。感染BA.5的鼻粘膜類器官中病毒(NP+)的陽性細胞數(shù)量明顯比感染W(wǎng)T的類器官中為多(圖A)。而且感染BA.5的類器官中會明顯地出現(xiàn)典型形態(tài)的合胞體(圖B)。</p> </section> </section> <section style="margin-bottom: -35px; outline-width: 0px; text-align: left; transform: translate3d(15px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 50px; height: 50px; vertical-align: top; overflow: hidden; border-radius: 100%; background-image: linear-gradient(to top, #76b0a6 0%, #86cabf 100%); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 5px; outline-width: 0px; text-align: center;"> <section style="outline-width: 0px; display: inline-block; width: 40px; height: 40px; vertical-align: top; overflow: hidden; border-radius: 100%; background-color: rgba(255, 255, 255, 0.98); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 4px; outline-width: 0px;"> <section style="outline-width: 0px; font-size: 20px; color: #004c47;"> <p style="outline-width: 0px;"><em style="outline-width: 0px;"><strong style="outline-width: 0px;">03</strong></em></p> </section> </section> </section> </section> <section style="outline-width: 0px; text-align: justify;"> <p style="outline-width: 0px;">&nbsp;</p> </section> </section> </section> <section style="margin-bottom: 15px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding-left: 70px; outline-width: 0px; display: inline-block; width: 596px; vertical-align: top; border-left: 8px double rgba(255, 255, 255, 0.98); border-bottom-left-radius: 0px; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right, #288c83, #59a8a0, #83c4bd, #ace1db, #d5fffa); box-sizing: border-box;"> <section style="margin-top: 6px; margin-bottom: 6px; outline-width: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row nowrap;"> <section style="padding-right: 15px; padding-left: 20px; outline-width: 0px; display: inline-block; width: 518px; vertical-align: top; border-left: 0px none #3e3e3e; border-bottom-left-radius: 30px; overflow: hidden; border-bottom: 0px none #3e3e3e; border-bottom-right-radius: 0px; border-top: 0px none #3e3e3e; border-top-left-radius: 30px; background-color: rgba(255, 255, 255, 0.98); flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="outline-width: 0px; transform: translate3d(1px, 0px, 0px);"> <section style="outline-width: 0px; text-align: left; font-size: 18px; color: #004c47;"> <p style="outline-width: 0px;"><strong style="outline-width: 0px;">研究意義</strong></p> </section> </section> </section> </section> </section> </section> <section style="margin-top: 15px; margin-bottom: 10px; outline-width: 0px;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">早前已有大量研究指出Omicron的高傳染性是由于免疫逃逸。</p> <p style="outline-width: 0px;">&nbsp;</p> <p style="outline-width: 0px;">周婕博士及袁國勇教授團隊表示：</p> </section> </section> <section style="margin-top: 10px; margin-bottom: 25px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; display: inline-block; width: 566.198px; vertical-align: middle; align-self: center; flex: 0 0 auto; background-color: #f8f9fd; height: auto; line-height: 0; border-radius: 5px; overflow: hidden; box-sizing: border-box; border: 1px solid #08706a;"> <section style="margin-top: 15px; outline-width: 0px; text-align: left;"> <section style="padding-right: 5px; padding-left: 5px; outline-width: 0px; display: inline-block; width: 40px; height: 30px; vertical-align: top; overflow: hidden; background-color: rgba(0, 0, 0, 0); box-sizing: border-box;"> <section style="outline-width: 0px; text-align: center; line-height: 0;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 30px;"><img style="outline-width: 0px; vertical-align: middle; width: 30px; height: auto; max-width: 100%; visibility: visible;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830498421.gif" width="30" height="21" data-ratio="0.7" data-type="svg" data-w="30" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830498421.gif" /></section> </section> </section> </section> <section style="outline-width: 0px;"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; text-align: justify; font-size: 14px; line-height: 2; color: #3e3e3e; box-sizing: border-box;"> <p style="outline-width: 0px;">這次在我們建立的人鼻粘膜類器官和氣道類器官研究中，發(fā)現(xiàn)<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">BA.5進化并提高新冠病毒的入侵效率，增強病毒在細胞間的傳播，從而大大增強感染復(fù)制的能力。</strong></span></p> </section> </section> <section style="margin-top: -5px; outline-width: 0px; text-align: right;"> <section style="padding-right: 5px; padding-left: 5px; outline-width: 0px; display: inline-block; width: 40px; height: 30px; vertical-align: top; overflow: hidden; background-color: rgba(0, 0, 0, 0); box-sizing: border-box;"> <section style="outline-width: 0px; text-align: center; line-height: 0;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 30px;"><img style="outline-width: 0px; vertical-align: middle; width: 30px; height: auto; max-width: 100%; visibility: visible;" src="https://editor-user.365editor.com/wechat/99/82/4969882/16847418306466.gif" width="30" height="21" data-ratio="0.7" data-type="svg" data-w="30" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/16847418306466.gif" /></section> </section> </section> </section> </section> </section> <section style="margin-top: 15px; margin-bottom: 10px; outline-width: 0px;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; font-size: 14px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">此研究讓團隊<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">從全新視角揭示BA.5變異株超強感染性和傳播能力的機制</strong></span>，為公共衛(wèi)生政策的實行提供了科學(xué)依據(jù)。<span style="outline-width: 0px; color: #08706a;"><strong style="outline-width: 0px;">團隊建立的呼吸道類器官培養(yǎng)系統(tǒng)可以廣泛地應(yīng)用于呼吸系統(tǒng)生理和疾病的研究。</strong></span></p> </section> </section> <p style="outline-width: 0px;">&nbsp;</p> <p style="outline-width: 0px;">&nbsp;</p> <section style="margin-bottom: -35px; outline-width: 0px; text-align: left; transform: translate3d(15px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 50px; height: 50px; vertical-align: top; overflow: hidden; border-radius: 100%; background-image: linear-gradient(to top, #76b0a6 0%, #86cabf 100%); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 5px; outline-width: 0px; text-align: center;"> <section style="outline-width: 0px; display: inline-block; width: 40px; height: 40px; vertical-align: top; overflow: hidden; border-radius: 100%; background-color: rgba(255, 255, 255, 0.98); box-sizing: border-box; border: 0px none #3e3e3e;"> <section style="margin-top: 4px; outline-width: 0px;"> <section style="outline-width: 0px; font-size: 20px; color: #004c47;"> <p style="outline-width: 0px;"><em style="outline-width: 0px;"><strong style="outline-width: 0px;">04</strong></em></p> </section> </section> </section> </section> <section style="outline-width: 0px; text-align: justify;"> <p style="outline-width: 0px;">&nbsp;</p> </section> </section> </section> <section style="margin-bottom: 15px; outline-width: 0px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap;"> <section style="padding-left: 70px; outline-width: 0px; display: inline-block; width: 596px; vertical-align: top; border-left: 8px double rgba(255, 255, 255, 0.98); border-bottom-left-radius: 0px; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right, #288c83, #59a8a0, #83c4bd, #ace1db, #d5fffa); box-sizing: border-box;"> <section style="margin-top: 6px; margin-bottom: 6px; outline-width: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row nowrap;"> <section style="padding-right: 15px; padding-left: 20px; outline-width: 0px; display: inline-block; width: 518px; vertical-align: top; border-left: 0px none #3e3e3e; border-bottom-left-radius: 30px; overflow: hidden; border-bottom: 0px none #3e3e3e; border-bottom-right-radius: 0px; border-top: 0px none #3e3e3e; border-top-left-radius: 30px; background-color: rgba(255, 255, 255, 0.98); flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="outline-width: 0px; transform: translate3d(1px, 0px, 0px);"> <section style="outline-width: 0px; text-align: left; font-size: 18px; color: #004c47;"> <p style="outline-width: 0px;"><strong style="outline-width: 0px;">研究團隊</strong></p> </section> </section> </section> </section> </section> </section> <section style="margin-bottom: 15px; outline-width: 0px; display: flex; flex-flow: row nowrap; text-align: center; justify-content: center; transform: translate3d(5px, 0px, 0px);"> <section style="margin-left: 7px; outline-width: 0px; display: inline-block; width: auto; vertical-align: top; border-left: 0px solid rgba(0, 121, 255, 0.08); border-bottom-left-radius: 0px; background-color: #f7f6f9; flex: 100 100 0%; align-self: flex-start; height: auto; box-sizing: border-box;"> <section style="margin-top: 15px; margin-bottom: -44px; outline-width: 0px; text-align: left; transform: translate3d(-8px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 17px; height: 17px; vertical-align: top; overflow: hidden; background-color: #08706a;"></section> </section> <section style="margin-top: 15px; margin-bottom: 10px; outline-width: 0px;"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; text-align: justify; color: #3e3e3e; line-height: 1.8; font-size: 14px; box-sizing: border-box;"> <p style="outline-width: 0px;">這項研究由港大醫(yī)學(xué)院臨床醫(yī)學(xué)學(xué)院微生物學(xué)系助理教授周婕博士和傳染病學(xué)講座教授袁或勇教授、荷蘭Hubrecht研究所Hans Clevers教授、復(fù)旦大學(xué)姜世勃教授領(lǐng)導(dǎo)。港大醫(yī)學(xué)院臨床醫(yī)學(xué)學(xué)院微生物學(xué)系研究助理教授李存博士、博士生黃晶晶、俞亦飛和萬智信為該研究的共同第一作者。</p> </section> </section> </section> </section> <section style="margin-top: 25px; margin-bottom: 5px; outline-width: 0px; text-align: center; line-height: 0;"> <section style="outline-width: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 566.198px; height: auto;"><img class="rich_pages wxw-img" style="outline-width: 0px; vertical-align: middle; width: 458px; height: 344px; max-width: 100%; visibility: visible; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830317683.gif" width="458" height="344" data-backh="425" data-backw="566" data-ratio="0.75" data-type="jpeg" data-w="1080" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684741830317683.gif" /></section> </section> <section style="outline-width: 0px; text-align: center;"> <section style="padding-right: 10px; padding-left: 10px; outline-width: 0px; text-align: justify; font-size: 12px; color: #3e3e3e; line-height: 1.8; box-sizing: border-box;"> <p style="outline-width: 0px;">港大醫(yī)學(xué)院揭示新冠病毒BA.5變異株高度傳染的機制。團隊成員包括：（從左至右）俞亦飛、黃晶晶、李存博士、萬智信、周婕博士、袁國勇教授、趙文俊博士、朱曉鑫和張舒心。</p> <p style="outline-width: 0px;">&nbsp;</p> </section> </section> <section style="margin-bottom: 15px; outline-width: 0px; display: flex; flex-flow: row nowrap; text-align: center; justify-content: center; transform: translate3d(5px, 0px, 0px);"> <section style="margin-left: 7px; outline-width: 0px; display: inline-block; width: auto; vertical-align: top; border-left: 0px solid rgba(0, 121, 255, 0.08); border-bottom-left-radius: 0px; background-color: #f7f6f9; flex: 100 100 0%; align-self: flex-start; height: auto; box-sizing: border-box;"> <section style="margin-top: 15px; margin-bottom: -44px; outline-width: 0px; text-align: left; transform: translate3d(-8px, 0px, 0px);"> <section style="outline-width: 0px; display: inline-block; width: 17px; height: 17px; vertical-align: top; overflow: hidden; background-color: #08706a;"></section> </section> <section style="margin-top: 15px; margin-bottom: 10px; outline-width: 0px;"> <section style="padding-right: 20px; padding-left: 20px; outline-width: 0px; text-align: justify; color: #3e3e3e; line-height: 1.8; font-size: 14px; box-sizing: border-box;"> <p style="outline-width: 0px;">其他參與作者包括港大醫(yī)學(xué)院臨床醫(yī)學(xué)學(xué)院微生物學(xué)系博士后趙文俊、博士生劉曉娟、研究助理張舒心、助理專職研究員蔡建飄、助理教授朱軒博士、臨床副教授陳福和醫(yī)生、系主任及臨床教授杜啟泓教授、南方醫(yī)科大學(xué)南方醫(yī)院李剛教授;以及廣州醫(yī)科大學(xué)附屬第一醫(yī)院廣州呼吸健康研究院楊子峰教授。</p> </section> </section> </section> </section> </section> </section> </section> </section> </section> <p style="display: none;">&nbsp;</p> </section>