<div data-page-id="doxcnOjeQeMkGHV8ft82bMxBdAg" data-docx-has-block-data="true"> <div class="image-uploaded gallery old-record-id-doxcneqkmgiIkugiYMhGTjEY8Mf" data-type="image" data-ace-gallery-json="{&quot;items&quot;:[{&quot;uuid&quot;:&quot;c57b37c1-ec94-44d0-b594-c0813a39a7a2&quot;,&quot;height&quot;:257,&quot;width&quot;:420,&quot;currHeight&quot;:257,&quot;currWidth&quot;:420,&quot;natrualHeight&quot;:257,&quot;natrualWidth&quot;:420,&quot;pluginName&quot;:&quot;imageUpload&quot;,&quot;scale&quot;:1,&quot;src&quot;:&quot;https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2FboxcnDzdL45yh1hcFQcebdTWHAh%2F%3Fmount_node_token%3DdoxcneqkmgiIkugiYMhGTjEY8Mf%26mount_point%3Ddocx_image&quot;,&quot;file_token&quot;:&quot;boxcnDzdL45yh1hcFQcebdTWHAh&quot;,&quot;image_type&quot;:&quot;image/jpeg&quot;,&quot;size&quot;:14879,&quot;comments&quot;:[]}]}"><span class="p"><img style="display: block; margin-left: auto; margin-right: auto;" 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style="text-align: justify;"><span class="p">根據(jù)昆士蘭大學(xué)對小鼠的一項研究，無針疫苗貼片可以比傳統(tǒng)的針頭疫苗更好地對抗COVID-19變體，如Omicron和Delta。</span></div> <div class="ace-line ace-line old-record-id-doxcnYgCmUsYa2QAwQ78TdOsUlb" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn0MG2mqyAIyICKYek9CqBTg" style="text-align: justify;"><span class="p">該研究與布里斯班生物技術(shù)公司Vaxxas合作進行，使用Vaxxas高密度微陣列貼片（HD-MAP）技術(shù)測試了Hexapro SARS-CoV-2刺殺疫苗，結(jié)果發(fā)現(xiàn)該貼片在中和COVID-19變體方面要有效得多。</span></div> <div class="ace-line ace-line old-record-id-doxcny6wQWwauQyEUwZcsDwsz5t" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn4Mgsgk808CisKypJjKqcrf" style="text-align: justify;"><span class="p">昆士蘭大學(xué)的Christopher McMillan博士說，疫苗貼片似乎比目前通過注射提供的SAR-CoV-2疫苗更有效地抵消了新變種。</span></div> <div class="ace-line ace-line old-record-id-doxcnoAO8icEyKSSSo9z6xKgpEb" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcna4C88OQCQgaAALGQNOOIFh" style="text-align: justify;"><span class="p">&ldquo;高密度微陣列貼片是一種疫苗遞送平臺，可將疫苗精確地輸送到富含免疫細胞的皮膚層中，&rdquo;McMillan博士說。</span></div> <div class="ace-line ace-line old-record-id-doxcnGaCMWCo284gqsF99dwonmg" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIoasgAMAWYKe0MMMtuFoYg" style="text-align: justify;"><span class="p">&ldquo;我們發(fā)現(xiàn)，與通過針頭施用的相同疫苗相比，通過貼片接種疫苗在對抗Omicron變體方面的效果大約高出11倍。</span></div> <div class="ace-line ace-line old-record-id-doxcnwGq4WoO4YqoGaOq2dH5xhe" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnE6uiCcCgSMgMGA3FwMuXXd" style="text-align: justify;"><span class="p">他說，結(jié)果比Hexapro疫苗更進一步。</span></div> <div class="ace-line ace-line old-record-id-doxcnQYyAGQ6WYY0i0E0RBRXo7f" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnyKeoyayKmUgs4MHpjPpl8e" style="text-align: justify;"><span class="p">&ldquo;到目前為止，我們通過貼片測試的每種疫苗類型，包括亞基，DNA，滅活病毒和偶聯(lián)物，與傳統(tǒng)的針頭疫苗接種方法相比，都能產(chǎn)生卓越的免疫反應(yīng)，&rdquo;他說。</span></div> <div class="ace-line ace-line old-record-id-doxcne806AWECyOscwPTl48VyVe" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn2MwaOeceUcA6QXcCPgzzdh" style="text-align: justify;"><span class="p">昆士蘭大學(xué)教授David Muller博士表示，由于COVID-19的新變種不斷涌現(xiàn)，目前可用的疫苗可能不那么有效，這讓研究人員處于十字路口。</span></div> <div class="ace-line ace-line old-record-id-doxcnq6KmeaKEI0IMqghESMXJbf" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn8E84kCMI2wuecL2KlJ52Eg" style="text-align: justify;"><span class="p">&ldquo;這種降低的有效性在Omicron變體中得到了突出，該變體在刺突蛋白中含有30多個突變，&rdquo;Muller博士說。</span></div> <div class="ace-line ace-line old-record-id-doxcnEOcEkgyICkyweetOkMcwQc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn2Iaw0cAGsAQ2WKsA0Lyz9f" style="text-align: justify;"><span class="p">&ldquo;大量的突變使病毒能夠逃避當(dāng)前疫苗產(chǎn)生的免疫反應(yīng)。</span></div> <div class="ace-line ace-line old-record-id-doxcnW4AIUKYakY4acjI3E1yOH5" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="image-uploaded gallery old-record-id-doxcnsCOwMGMOKIsA0iL7R5vAZg" data-type="image" 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old-record-id-doxcnqkWKO6kU2o62kXh7HwSQoc" style="text-align: justify;"><span class="p">&ldquo;然而，貼片技術(shù)有可能在我們的武器庫中提供一種新的 - 更有效的 - 武器，而此時新變種正在迅速變異。</span></div> <div class="ace-line ace-line old-record-id-doxcn0sYUAuaKwIWgohuqVD24Qf" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnEgouck6YaUAYiMPneQ93Yc" style="text-align: justify;"><span class="p">&ldquo;這些貼劑不僅對新出現(xiàn)的變異更有效，而且比針頭疫苗更容易管理。</span></div> <div class="ace-line ace-line old-record-id-doxcnwQmUiyka4MkAGmCBrQVNQf" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnyWG8k6QsAa6A2mA9BpQmRf" style="text-align: justify;"><span class="p">&ldquo;但是，重要的是要強調(diào)，現(xiàn)有疫苗仍然是對抗這種病毒引起的嚴重疾病的有效方法，現(xiàn)在不是放松警惕的時候。</span></div> <div class="ace-line ace-line old-record-id-doxcnUA48OKqAMu8y2hfWvbYjJY" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcna0wOcokI4Aqmo5Rs1gZVbf" style="text-align: justify;"><span class="p">Vaxxas首席執(zhí)行官David Hoey表示，這進一步證明了該技術(shù)平臺在幫助各國更好地應(yīng)對當(dāng)前和未來大流行等全球突發(fā)衛(wèi)生事件方面可能具有改變游戲規(guī)則的潛力。</span></div> <div class="ace-line ace-line old-record-id-doxcnKkwESEcOscMYiD1txaXQos" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnesUOKuK80YmeSv6DeB3yBl" style="text-align: justify;"><span class="p">&ldquo;我們正在繼續(xù)擴大我們的制造能力，并加速產(chǎn)品開發(fā)，為大規(guī)模臨床試驗做準(zhǔn)備，&rdquo;他說。</span></div> <div class="ace-line ace-line old-record-id-doxcn2gia8SuQEEUO4yuCSL8Iif" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnsUaO8UyKy4SOCizBuWl8sd" style="text-align: justify;"><span class="p">&ldquo;這包括在布里斯班建造我們的第一個生產(chǎn)設(shè)施，以支持我們的HD-MAP候選疫苗向商業(yè)化過渡，包括Hexapro COVID-19貼片。</span></div> <div class="ace-line" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn0mWOiWm6w0gYEZKUWnnufc" style="text-align: justify;"><span class="p">該研究已發(fā)表在<em>《疫苗》上</em>。</span></div> <div class="ace-line ace-line old-record-id-doxcnGmgyskMQGAuWyoBo2sgdhc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnukyyKQmOKY0ckTaSLKtaYg" style="text-align: justify;"><span class="p">該研究由David Muller博士獲得的Advance Queensland Industry Research Fellowship資助。</span></div> <div class="ace-line ace-line old-record-id-doxcngMEo4E48IIi6oslxCx5XPm" style="text-align: justify;">&nbsp;</div> </div>